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Vol 37(2021) N 6 p. 48-57; DOI 10.21519/0234-2758-2021-37-6-48-57
S.N. Marzanova1, D.A. Devrishov1, I.S. Turbina2, Ya.I. Alekseev3, N.V. Konovalova3, and N.S. Marzanov4*

Genetic Diagnostics of FANC1BY Mutation in Representatives of the Holstein Breed and Its Crosses

1K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, Ministry of Agriculture of the Russian Federation, Moscow, 109472, Russia
2Head Center for the Reproduction of Farm Animals, Ministry of Agriculture of the Russian Federation, Bykovo, Moscow Oblast, 142143, Russia
3Syntol, Moscow, 127550, Russia
4L.K. Ernst Federal Research Center for Animal Husbandry, Ministry of Education and Science of the Russian Federation, Dubrovitsy, Moscow Oblast, 142132, Russia

*nmarzanov@yandex.ru
Received - 04.07.2021; Accepted - 08.09.2021

References

The article is devoted to the development and use of a method for diagnosing the source of Brachyspina Syndrome, or short spine, in the Holstein breed and its crossbreeds. Representatives of this breed are the most highly productive animals in the world for milk. The development of a diagnostic method for breed-specific hereditary carriers is an important task in dairy farming. In this regard, the authors have proposed a Patent and a Reagent Kit for the detection of normal FANC1TY and mutant FANC1BY alleles in the Holstein breed and its crossbreeds. The frequency of occurrence of genotypes formed by these alleles in different sex and age groups of animals in the Holstein breed and its high-blooded hybrids was studied. Historical data related to the founders, from whom the spread of the mutant FANC1BY allele within the Holstein breed itself and its crossis in the USA, Canada and Russia began, has presented. The development of a diagnostic method for the mutant FANC1BY allele will make it possible to stop spreading of the Brachyspina Syndrome source. The proposed method will make it possible, in the early stages, to form healthy groups of breeding animals (bulls, replacement bulls, bull-reproducing cows), thereby laying the foundation for creating a high-quality livestock in the regions where the Holstein breed and its numerous crossbreeds are bred.

cattle, Holstein breed, crossis, genotype, FANC1BY mutation, allele, Brachyspina syndrome



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